The National Institute of Public Health
Šrobárova 49/48
100 00, Praha 10

Phone: 00420 26708 1111
E-mail: podatelna@szu_cz

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National Reference Laboratory for Meningococcal Infections

  The NRL is accredited to ČSN EN ISO/IEC 17025 as a test laboratory and to ČSN EN ISO 15189 as a public health laboratory by the Czech Accreditation Institute.

Head: Pavla Křížová, M.D., Ph.D.

  • verifies the identification of Neisseria, N. meningitidis and serogrouping results as referred by microbiology laboratories in the Czech Republic;
  • performs molecular typing (MLST, PorA, FetA, PenA, MenB vaccine antigen genes) of N. meningitidis isolates from microbiology laboratories in the Czech Republic;
  • maintains the collection of N. meningitidis strains from invasive meningococcal disease, healthy carriers and respiratory diseases (more than 5000 isolates collected since 1971);
  • maintains the database of microbiological, epidemiological, and clinical data related to the collection of N. meningitidis strains;
  • performs PCR detection and typing of N. meningitidis, H. influenzae, and S. pneumoniae from clinical specimens;
  • cooperates with the NRL for Antibiotics in N. meningitidis antimicrobial susceptibility testing;
  • organizes the nationwide invasive meningococcal disease surveillance and processes the data submitted;
  • provides background data for the anti-meningococcal vaccination strategy in the Czech Republic;
  • has been involved in the nationwide external quality assessment schemes (EQAS);
  • provides postgraduate lecturing and training;
  • participates in the international projects EMGM (European Monitoring Group on Meningococci), MenNet (Impact of Meningococcal Epidemiology and Population Biology on Public Health in Europe), IBD-LabNet (Invasive Bacterial Disease-Laboratory Network);
  • reports data to The European Union Invasive Bacterial Infections Surveillance Network (EU-IBIS), The European Surveillance System (TESSy), global database of N. meningitidis multilocus sequence typing (MLST), global database of non-capsular antigen sequence typing and DNA sequencing of penicillin resistance genes of N. meningitidis, and EMERT (European Meningococcal Epidemiology in Real Time);
  • has been involved in international projects on the development of the vaccine against N. meningitidis;
  • successfully participates in the international external quality assessment schemes (EQAS).