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Human Biomonitoring


Bisphenols in Czech children

In 2019, the content of bisphenols A, F and S in archived urine samples of children from the Children's Health study was analyzed. 


 

Toxic organic compounds in human milk, 2017

The study targeted the presence of polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs), perfluorinated compounds (PFCs) and brominated flame retardants (BFRs) and their derivatives, including some ‘new’ BFRs. The content of trans-fatty acids in part of the human milk samples was analysed as well. 


 

Phthalate metabolites in children

The monitoring of the urinary content of selected phthalate metabolites extends the international project Democophes aimed at mothers and their children aged  6-11 years [1]. In 2016, the monitoring was carried out in five localities – Prague, Liberec, Ostrava, Žďár nad Sázavou, and Kutná Hora. The target population were children aged five and nine years.  The study cohort consisted of 419 children (162 five-year-olds and 257 nine-year-olds). The samples collected were 400 urine specimens. Analyses were performed in the laboratory of the National Institute of Public Health in Prague using high performance liquid chromatography (HPLC) along with tandem mass spectrometry (MS/MS). 


 

Essential elements and Vitamin D in children

In 2016, the monitoring was carried out in five localities – Prague, Liberec, Ostrava, Žďár nad Sázavou, and Kutná Hora. The target population were children aged five and nine years. The study cohort consisted of 419 children (162 five-year-olds and 257 nine-year-olds). The samples collected were 419 blood serum specimens, 418 whole blood specimens, and 400 urine specimens. The whole blood and urine samples were analysed for selected essential trace elements (iodine – I, manganese – Mn, selenium - Se, and zinc – Zn), and blood serum was analysed for a vitamin D metabolite - 25-hydroxyvitamin D (25(OH)D). 


 

Toxic metals in children, 2016

In 2016, the monitoring was carried out in five localities – Prague, Liberec, Ostrava, Žďár nad Sázavou, and Kutná Hora. The target population were children aged five and nine years. The samples collected were 418 whole blood specimens, and 400 urine specimens. The whole blood and urine samples were analysed for selected toxic metals (cadmium – Cd, lead – Pb, mercury – Hg, and arsenic – As).The toxic elements were determined in mineralized (blood) and non-mineralized (urine) samples using inductively coupled plasma mass spectrometry (ICP-MS), with the exception of mercury, which was detected directly from the original samples using the AMA 254 advanced mercury analyzer. Blood and urine analyses were performed in the accredited laboratories of the National Institute of Public Health in Prague.


 

COPHES-DEMOCOPHES Project

The Czech Republic was one of 27 European states participated in the project carried out in 2009−2012. The aim of the project was to develop harmonised a European-wide human biomonitoring framework. Suggested methods (respondent recruitment, collection of biological material samples and their analysis, questionnaires developed for the interview, statistical analysis of survey data) were tested in the pilot feasibility study DEMOCOPHES (Demonstration of a study to Coordinate and Perform Human Biomonitoring on a European Scale).


 

Reference values

Human Biomonitoring has been regularly realized since 1996 in the Czech Republic. So far, the adult blood donors, children aged 8-10 years and primiparas were the objects of the follow-up. For the period 2005 to 2009 the reference values of toxic chemicals (lead, cadmium, mercury, PCBs) for these population groups were evaluated and compared with previous monitoring periods.    


 

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